Fatty Foods Make Us Hungry—And Fat

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Here’s a clue to the virulence of the obesity epidemic. New research suggests the hunger hormone ghrelin is activated by fats from the foods we eat, not those made in the body.

This natural process was designed to optimize metabolism and promote the storage of body fat. And this was useful when food was hard to come by and we had to work physically hard to get it.

Now it backfires on us in the form of fat.

Ghrelin—the hunger hormone—is believed to accumulate during periods of fasting and is found in the body in high concentrations just before meals. It’s activated by a fatty acid added by an enzyme called GOAT. Originally it was assumed that the fatty acids attached to ghrelin by GOAT were produced by the body during fasting.

But the new data published in Nature Medicine suggest the fatty acids needed for ghrelin activation come directly from ingested dietary fats.

Exposed to fatty foods, mice with more GOAT gain more fat. Mice without GOAT gain less fat since their brain never receives the signal to store the fat.

Why am I worried that this will lead to a pharmaceutical fix that will allow us to continue overeating without getting fat?
 

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SIX TRUTHS

Reclaiming power from those who abuse it often starts with telling the truth. And in "This Is How Authoritarians Get Defeated," MoJo's Monika Bauerlein unpacks six truths to remember during the homestretch of an election where democracy, truth, and decency are on the line.

Truth #1: The chaos is the point.

Truth #2: Team Reality is bigger than it seems.

Truth #3: Facebook owns this.

Truth #4: When we go to work, we're in the fight.

Truth #5: It's about minority rule.

Truth #6: The only thing that can save us is…us.

Please take a moment to see how all these truths add up, because what happens in the weeks and months ahead will reverberate for at least a generation and we better be prepared.

And if you think journalism like Mother Jones'—that calls it like it is, that will never acquiesce to power, that looks where others don't—can help guide us through this historic, high-stakes moment, and you're able to right now, please help us reach our $350,000 goal by October 31 with a donation today. It's all hands on deck for democracy.

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